CTRL-S -> SAVE doesn't work after editing saved-to-local webpage

[Budi]

I did CTRL-S -> SAVE to save a webpage and close it and the browser altogether.
Then I reopen Cent, reload the local-saved page and go into developer tools and modified some URL there..
But when I next did CTRL-S -> SAVE and close it and reopen it, the modification gives no effect at all.
Simply looks like the save command not work at all.. please help me I really need this capability.. Thank so much in advance