STABLE version -- 5.0.1002.354

[Admini]

It feels like smooth-scrolling makes little difference relative to the mouse.
I turned it off/on in both Cent and Chrome, no change.
Safe mode in Cent feels like it makes the mouse more responsive, but I can't use it all the time(.

I'd like to understand the reason for the change in mouse feel, how the mouse feels so light in regular Chrome, but in Cent it feels heavier.

If there is no problem in safe mode, the problem may be some extension or hardware acceleration.
You can also try upgrading the hardware drivers firstly.