STABLE version -- 5.0.1002.354

[Admini]

I have a problem concerning the mouse.
When I run Cent, the mouse seems to become less responsive, as if it becomes heavier and the system's response to the mouse becomes worse
But when I run the most ordinary Chrome, my mouse starts to become easy to move, as if my mouse has dropped a couple of kilograms and it is easier for it to move. As if the mouse response in the system is getting much better with regular Chrome

What could this be related to?

Have you tried it in safe mode?
Or try changing chrome://flags/#smooth-scrolling to "Disabled".